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A new review suggests that taking both a GLP-1 medication, and a medication that combines both naltrexone and bupropion into one pill, may be helpful for those who are not responding to GLP-1s alone

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Realistic expectations should account for the fact that genuine tissue regeneration requires weeks to months, not days

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Bibcode:2009EnvMM..50..285S

GI side effects during the initial dose escalation phase are expected and typically improve with continued use