We have previously shown that, in the region surrounding the NPEY motif, 4 out of 16 residues differ between the IR and IGF1R (equivalent to Pro963, Ser968, Leu973, and Ser976 in the IR) and by systematic substitution of each of these residues showed that only replacement of leucine-973, the residue in the +1 position following the NPEY motif, with phenylalanine results in a shift from binding IRS-1 to binding Shc in a receptor pull-down assay (14)
If you want a deeper education on formulation and delivery, the What Is Liposomal Glutathione
Science 281 : 13091312 Liu X, Kim CN, Yang J, Jemmerson R and Wang X (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c
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Dabei weist die Substanz antioxidative Eigenschaften auf und spielt eine bedeutende Rolle fr den Aufbau von Cystein
doi: 10.1016/S1096-7192(02)00169-5 17