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Because preservative effectiveness is only required to be demonstrated for 28 days after first entry, standard multiple-dose vial practice, reflected in CDC injection safety guidance, is to date the vial at first puncture and discard it 28 days later

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doi: 10.1002/gps.1856 81 WatanabeHIshidaSKonnoYMatsumotoMNomachiSMasakiKet al

Bethany Tennant, N.D., C.N.S., is a licensed naturopathic physician and certified nutrition specialist

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doi:10.1056/nejmoa2511774 8.Jastreboff AM, Kaplan LM, Fras JP, et al