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TDP-43 is an important pathological protein because the abnormal accumulation of misfolded, wildtype (WT) cytoplasmic TDP-43 into inclusions is the characteristic pathological hallmark of ~97% of ALS patients (sALS and fALS

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This is a hard ceiling, not an estimate methionine and inositol oxidise rapidly in aqueous solution, and degradation accelerates beyond the 72-hour mark

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