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Altered PC composition in cell membranes disrupts insulin receptor localization and downstream signaling cascades, impairing glucose uptake and insulin sensitivity in adipocytes and skeletal muscle cells

2002 Apr 1(225):148-55

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Thus, the negative regulation of gliotoxin biosynthesis via GtmA must be counter-balanced by GliT activity to avoid Methyl/Met cycle dysregulation, SAM depletion and trans consequences on global cellular biochemistry in A