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Additionally, we ensure that it is paired with proper nutrition and lifestyle changes for the best results

Szpunar for her help in creating Table 2 and A

Current NHS challenges: Demand for GLP-1 receptor agonists substantially exceeds supply, with many NHS areas implementing waiting lists or restrictive prescribing policies

Zepbound is designed as a long-term treatment for chronic weight management

Along with a significant pool of preclinical data on the effect of GLP-1RAs (including exendin-4) on PD models in experimental animals, showing a decrease in the loss of dopaminergic neurons and accumulation of -synuclein in the brain, a decrease in mitochondrial dysfunction and expression of pro-inflammatory mediators such as tumor necrosis factor (TNF)- and interleukin IL-1 [61], promising data from clinical studies on the use of GLP-1RAs in PD have been obtained [62]

Medical review is important if side effects are severe, blood sugar is unstable, or symptoms suggest dehydration, pancreatitis, or gallbladder problems