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10.1371/journal.pone.0092842 55

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Importantly, DNA damage induces DNA-binding complex MRN (Mre11/Rad50/Nbs1), which is required for ATM activation (Lee and Paull, 2007), and GH rapidly dephosphorylates Mre11 and Rad50 in 3T3-F442A preadipocytes according to the phosphoproteomics results