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Additionally, the magnitude of clinical effects differs substantially

[1] [11] This mechanism helps improve glycaemic control whilst also promoting modest weight loss as part of diabetes management

Expert consensus suggests considering pharmacotherapy when there is: Significant weight regain from nadir weight BMI 27 kg/m with obesity-related comorbidities or BMI 30 kg/m Absence of anatomical complications requiring surgical revision Adequate adherence to nutritional and behavioral recommendations Patient willingness to engage in long-term pharmacotherapy The American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE) guidelines emphasize that pharmacologic therapy should complement, not replace, lifestyle interventions and ongoing bariatric surgical follow-up

However, with proper guidance and support, many patients find that they can adapt to this mode of administration

Autoimmune and inflammatory conditions

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