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Rosenthal AF (2003)

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found that selenium deficiency in RAW 264.7 macrophages increases oxidative stress and enhances iNOS expression and NO production through heightened NF-B activation, suggesting seleniums key role in regulating inflammatory responses (Prabhu et al., 2002)

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After discontinuing treatment, a regression of some behavioral gains was observed, implying that ongoing supplementation may be essential for maintaining the improvements in ASD symptoms