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Vitamins fall into two groups: fat-soluble and water-soluble, and this distinction is central to B12's safety profile

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The deletion of Dnmt1 in excitatory neurons of the dorsal forebrain in mice, although these mice are viable into adulthood, results in hypomethylation, dysregulation of gene expression, defects in dendritic branching, and progressive apoptotic degeneration of dorsal forebrain [74]