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Phase 3 clinical trials are under way (see ClinicalTrials.gov for current registered studies), and whilst early Phase 2 results are encouraging, retatrutide is not legally available as a prescribed medicine in the UK outside of approved clinical trial settings

Published clinical trials have reported large average body weight reductions in obesity protocols, dose dependent HbA1c and weight changes in type 2 diabetes protocols, and liver fat imaging endpoints in defined substudies, which is why retatrutide is now a major reference point in modern metabolic peptide research

51 The impact of GLP-1RAs on patients with obesity and HFpEF was recently demonstrated in the STEP HFpEF trial

A GI bleed, menorrhagia, or hemorrhoidal bleeding must appear in the note, and the bleeding source code is sequenced separately

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95% CI, 0.72-0.98) and rectal cancer (HR = 0.72