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When it crosses the blood-brain barrier and binds to c-Met, it initiates synaptogenesis: new dendritic spines form, synaptic connections strengthen, and neurons that were alive but under-connected begin to integrate more fully into functional networks

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There are numerous factors that affect adherence, including patient and/or physician resistance to intensifying treatment regimens, financial burden, and the complexity of the medication regimen

doi: 10.5853/jos.2017.00234 52 MaQLiRWangLYinPWangYYanCet al

Bailey, K