Evidence for antiviral activity of glutathione: in vitro inhibition of herpes simplex virus type 1 replication
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Without GSH depletion, viability of mock- and GSTP1 -transfected cells was comparable for all treatments
Under iron overload or hypoxic conditions, autophagy plays a positive role in scavenging ROS, preserving mitochondrial integrity, counteracting metabolic insults, avoiding apoptosis and protecting cells (10)
While initiation of motor neuron degeneration appears cell-intrinsic, other cell types including astrocytes, microglia, and T-lymphocytes are key components in the disease progression of ALS, and cell transplantation could more effectively be targeted at replacing these cell types rather than motor neurons