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Unlike older compounds in its class, it does not significantly alter cortisol or prolactin levels during observations

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Efficacy and safety of once-weekly tirzepatide for weight management compared to placebo: an updated systematic review and meta-analysis including the latest SURMOUNT-2 trial

However, within-class differences emerged: liraglutide was associated with a greater albuminuria reduction (OR 0.44, 95% CI 0.040.85) but a higher frequency of 30% eGFR decline (OR 2.63, 95% CI 1.076.45) compared with dulaglutide

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