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Clinical severity was graded as 0 (normal), 0.5 (erythema and edema in only one digit), 1 (erythema and mild edema of the footpad, or ankle or two to five digits), 2 (erythema and moderate edema of two joints [footpad or ankle, two to five digits]), 3 (erythema and severe edema of the entire paw), or 4 (reduced swelling and deformation leading to incapacitated limb) 68

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It is said to be able to eliminate any signs of aging with all of its unique features

Skandov MD et al

doi: 10.1002/prp2.1144 77 SchmahmannJ

However, while p53 modulates SLC7A11 expression, the expression and activity of SLC7A11 and GPX4 are not associated with SAT1, and only ferrostatin-1 can inhibit ROS-induced ferroptosis in Tet-on cells (Ou et al., 2016)