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As GLP-1R mRNA in the aortic tissue was below the level of quantification in both animal models, it seems likely that GLP-1Rs in other tissues, rather than direct action of liraglutide or semaglutide on the vascular bed, contribute to the mechanism of gene regulation

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Additionally, the burning may be related to injection technique variables including needle depth, injection speed, or inadvertent intradermal administration rather than proper subcutaneous placement

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