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It has been shown to be cyclic due to a disulfide bridge between two cysteine residues

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Together these data suggest that these inflammatory cytokines mediate the increase in hFAP mineralization and NHO in mice in response to Pam2CSK4 and Pam2CSK4 via TLR2, similar to the induction of these cytokines in response to LPS via TLR4 that we previously demonstrated [16, 32]

doi: 10.1146/annurev.physiol.59.1.257 23 SchjoldagerBMortensenPEMyhreJChristiansenJHolstJJ