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In old rats with OVX-induced osteoporosis, exendin-4 decreased the concentration of C-terminal cross-linked telopeptides of type I collagen (CTX-1) and the urinary deoxypyridinoline (DPD)/creatinine ratio (31)

Its coupling to GABA receptors-GABARs (/A, /B, /C) and their subunits induces the opening of K + ion channels to allow for the efflux of K + and the influx of Cl , resulting in hyperpolarization and a decrease in neuronal excitability (Sarasa et al., 2020)

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Current research on semaglutide extends well beyond its approved indications, with numerous ongoing trials investigating potential applications in various disease states

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