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This entire process dramatically reduces the compound's overall bioavailability compared to injection

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Histopathology and immunohistochemistry of pancreatic islets in fibrocalculous pancreatic diabetes

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Fromenty et al., 1990b)

Similarly, in age-related macular degeneration (AMD), pathological alterations involve choroidal neovascularization, choroidal capillary proliferation and aberrant basement membrane architecture (82)