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In my attempt to be brave, I tried to tell myself these, hopefully, rarely ever happen, signed the waiver, and crossed my fingers that things would go smoothly...and thankfully they did

As expected, the NTAPP-induced nuclear -catenin was abrogated by treatment of endo-IWR1, an inhibitor of canonical Wnt/-catenin signaling

This leads to the release and cytoplasmic translocation of p53, which can subsequently activate transcription-independent pro-apoptotic signaling (Figures 6A,B)