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Drug-specific monitoring schedule | Drug | Monitoring parameter | Timing after GLP-1 start | |---|---|---| | Warfarin | INR | 2 weeks, 4 weeks, then per standard | | Levothyroxine | TSH | 6 to 8 weeks | | Cyclosporine/tacrolimus | Trough level | Weekly for first 8 weeks | | Oral contraceptive | Add barrier method | For first 4+ weeks per Ozempic label | | Digoxin | Serum digoxin, ECG if symptomatic | 4 weeks | | Lithium | Serum lithium | 2 to 4 weeks, especially if nausea reduces fluid intake | What the Clinical Trial Data Actually Show Most large GLP-1 outcome trials were not designed to measure drug-drug interactions, but pharmacokinetic sub-studies and post-marketing data fill some gaps

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