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Liraglutide (Saxenda) another GLP-1 receptor agonist, recommended by NICE (TA664) for use in specialist weight management services under defined eligibility criteria, including BMI thresholds and the presence of weight-related comorbidities

Most side effects peak around day 3 to 5 post-injection, then gradually improve as your body acclimates to the medication's mechanism

The studies on potential DDI with GLP1RAs showed absence of clinically significant effects on the PK and PD of drugs from the four BCS classes

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Crucially for understanding gastrointestinal side effects, GLP-1 medications slow gastric emptying the rate at which food moves from the stomach into the small intestine

Approved agents in this space include sermorelin (FDA-approved as a diagnostic agent