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A limitation with the use of GLUTag cells, as well as other models for epithelial cells, is that the cells have lost their polarization, which may affect the amino acid sensing mechanisms, as different amino acid transporters are situated on the apical compared to the basolateral membrane [28]

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Full phase 3 data for orforglipron in people with both obesity and T2D were reported in November 2025 and for obesity without diabetes in September 2025