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Both drugs substantially reduced lifetime incidences of obesity, diabetes, and CVDpreventing up to 45,609 obesity and 20,854 diabetes cases per 100,000 individualsand yielded the largest incremental Quality-Adjusted Life Year (QALY) gains (0.35 for tirzepatide

(iii) Lipid-associated macrophages (LAMs), defined as Trem2 hi , Spp1 hi , Cd9 hi , Fabp5 hi and Ccr2 hi

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However, the burden of gastrointestinal side effects was confirmed in the high-dose group