Representative images of subcutaneous tumours of Karpas299 cells expressing a doxycycline-inducible shRNA against either GFP (control) or UGDH implanted in mice given sucrose-water with or without doxycycline (doxy, 2 g/L)
This study, which used confocal laser scanning microscopy, showed significant improvement with the collagen treatment in the structural aspects of facial skin, while no improvements were found in the placebo group
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The results showed that the overall response rate was 91%, with a complete response rate of 73% and a partial response rate of 18%, indicating that this treatment plan has significant clinical efficacy [134]
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