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Thyroid Cancer or Family History of MEN-2 Though very rare, there is a risk of the development of a specific type of thyroid cancer when taking Semaglutide, called Medullary Thyroid Cancer
Ideal candidates typically include adults with type 2 diabetes who have inadequate glycaemic control (HbA1c above individualised target) despite treatment with metformin and/or other oral agents, particularly those with additional cardiovascular or renal risk factors
Insulin + GLP-1: Can be combined, often allowing significant insulin dose reduction
Kidney outcomes with glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, dipeptidyl peptidase-4 inhibitors, and sulfonylureas in type 2 diabetes and moderate cardiovascular risk
Among a subset of patients with A1c 9%, the mean A1c change was 2.7% [37]