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Allergy risk is very low, but not zero

Active cancer is a relative contraindication: because GHK-Cu promotes cell growth, providers avoid it in uncontrolled malignancy (though ironically it also has anti-cancer gene effects)

For instance, free radicals are involved in cell signaling pathways that regulate vascular tone, immune response, and apoptosis

An in vitro UC model was also established in mouse peritoneal macrophages (MPMs) using lipopolysaccharide (LPS), and a co culture model was constructed using mouse colonic epithelial cells (MCECs) and MPMs to examine the role of GHK Cu in promoting mucosal healing