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Other mucosal sites are less commonly affected

Most community protocols use a 24-week staggered titration to reach maintenance, then run open-ended at maintenance with periodic re-evaluation

So yeah, it was kind of almost like a specialization looking for something to treat

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135,136 The underlying mechanism is that these cells lacking IDH2 show enhanced invasive behavior due to the increase in matrix metalloproteases, which depend on the NF-B pathway

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