Do not rely on thirst signals because they are unreliable on this medication
While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)
Interestingly, some women with PCOS might actually experience improved menstrual regularity since GLP-1 drugs lower insulin, a major contributor to irregular periods in women with PCOS
Levocarnitine is an amino-acid derivative essential for mitochondrial fatty-acid transport, and this injectable formulation is used to treat or prevent clinically significant carnitine deficiency in conditions such as primary systemic carnitine deficiency, certain inborn errors of metabolism, and end-stage renal disease on dialysis
[PubMed ID: 38966316]
A British study found lauryl glucoside to cause skin sensitivity for some people