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Med spas, telehealth startups, weight-loss-only clinics: many are happy to write a prescription after a short online questionnaire

Long-term safety is uncertain

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A blood clot in the eye can look frightening, but not all cases are serious

Contact your GP or prescribing clinician if: Fatigue is severe, persistent, or progressively worsening despite self-management strategies Tiredness is accompanied by dizziness, fainting, or significant weakness You experience symptoms suggesting dehydration (dark urine, dry mouth, reduced urination) Fatigue occurs alongside chest pain, shortness of breath, or palpitations You notice signs of depression, such as persistent low mood, loss of interest in activities, or changes in sleep patterns beyond simple tiredness Gastrointestinal symptoms (nausea, vomiting, diarrhoea) are severe or preventing adequate nutrition and hydration For urgent advice when your GP is unavailable, call NHS 111

Which blood pressure medications may need closer monitoring with semaglutide