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People with chronic kidney disease or frailty may have specific protein requirements and should discuss individual targets with a registered dietitian

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Tamoxifen and other ER ligands are defined as selective estrogen receptor modulators (SERMs), in that they induce tissue-selective ER agonist or antagonist effects depending on the interaction with tissue-selective transcriptional coregulators that are recruited by each ligand-specific receptor conformation (McDonnell et al., 2021)