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Tirzepatide and Phentermine Together: UK Safety Guide Mounjaro (tirzepatide) and phentermine (Adipex) are both prescribed for weight loss, but combining them is not routinely recommended in UK clinical practice

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[2] Since then, several other GLP-1 agonists have been developed and approved for clinical use, including liraglutide (Victoza), dulaglutide (Trulicity), semaglutide (Ozempic and Wegovy), and Tirzepatide (Mounjaro and Zepbound)

Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

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