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TGF-1 + IL-1 promotes NLRP3 inflammasome activation, glycolysis and histone lactylation in lung fibroblasts Since fibroblasts play a central role in pulmonary fibrosis, primary mouse lung fibroblasts were isolated and cultured for further experiments

Conversely, others and our laboratory have demonstrated that NO can favor GSH synthesis via the NEFL2-mediated transcription of GCL (Cortese-Krott et al., 2009)

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Consider periodic attempts to step down to H2 blockers or lifestyle management alone

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