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AOD-9604 acts through a dual mechanism: acutely, it stimulates lipolysis and energy expenditure through receptor-independent pathways
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However, these observations have not been replicated in nonhuman primates or humans and are believed to be a rodent phenomenon due to the higher density of GLP-1R on rodent C cells, so the responses obtained on rodents may not be relevant to primates (Samson and Garber, 2013
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GLP-1 drugs have garnered an increasing amount of media attention and some notable celebrity endorsements in the U.S., with much of the focus on their use for weight loss, though many of these drugs are also prescribed to treat diabetes or reduce risk of heart attack or stroke
No comprehensive, long-term human safety studies have been published
![glp-1 agonist drug list of glp 1 agonists current and its analogs [36-39] glp 1 names list Types of GLP-1 Medications for](https://www.researchgate.net/publication/371322849/figure/tbl1/AS:11431281165596278@1686056417230/List-of-current-GLP-1-and-its-analogs-36-39.png)
