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This is significant because age-related sleep disruption often involves not just melatonin deficiency but broader circadian gene dysfunction

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The P protein catalyzes the decarboxylation of glycine and transfers the methylamine residue (CH 2 -NH 2 ) to the lipoyl moiety of the H protein

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In some countries hydroxocobalamin has completely replaced cyanocobalamin as first choice for vitamin B 12 therapy because it is retained in the body longer and can be administered at intervals of up to three months