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The LNP-mRNA therapy eliminated pulmonary fibrosis and restored the ECM environment, which increased the plasticity of AT2 and Pclaf + cells to rescue AT1 cell population (Fig

While the regulation of MTHFR activity is closely controlled by SAM at C-terminal regulatory domain, more studies indicated that the human MTHFR enzyme activity is also regulated by multiple phosphorylated sites on a serine-rich N-terminal extension region 20

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Mol Cell , 35:479489