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An experimental study evaluated its effects in a mouse model of chloroquine-induced itch

(28) The crude incidence rates of amputation were 6.1 per 10,000 person-years for GLP-1s, 1.5 for SGLT-2 inhibitors, 4.6 for DPP4-Is, and 1.9 for other agents

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3.1.2 Safety In total, 21 TEAEs were reported in 11 participants: 14 events were reported in eight participants (57.1%) with normal renal function, two in one participant (14.3%) with mild renal impairment, and five in two participants (28.6%) with moderate renal impairment (Table 3)