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Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist, a type of medication that mimics the natural hormone GLP-1 your body produces

In fact, many patients experience improved blood sugar control alongside weight loss

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We identify a missense variant in GLP1R that is associated significantly with increased efficacy of GLP1 medications ( P = 2.9 10 10 ), with an additional 0.76 kg of weight loss expected per copy of the effect allele

2.3 TR-FRET surface receptor binding assays HEK293-SNAP-GLP-1R cells were labelled in suspension with SNAP-Lumi4-Tb (40 nM) for 1 hour at room temperature in complete medium

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