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References Sean Wharton et al, Once-weekly semaglutide 72 mg in adults with obesity (STEP UP): a randomized, controlled, phase 3b trial, The Lancet Diabetes and Endocrinology, Volume 13, Issue 11p949-963November 2025, DOI: 10.1016/S2213-8587(25)00226-8 Higher dose of semaglutide provided average weight loss of 21% in people with obesity with a third achieving 25% or more according to data presented at ADA, Press Release, and Novo Nordisk Wharton, S, et al

Neuronal dysregulation in the hypothalamus is a major pathological hallmark of obesity 7

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35 JiaB.SunM.SunX.LiR.WangZ.WuJ.et al (2016)