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In most cases, this change is mild and not dangerous, but you should monitor symptoms and contact a healthcare provider if they persist or worsen

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In terms of mechanisms, GLP-1RAs can block C/EBP homologous protein (CHOP)-mediated endoplasmic reticulum (ER) stress via attenuating the irreversible electroporation (IRE)- unfolded protein response (UPR) [85]

More recently, a phase 2 trial published in the New England Journal of Medicine showed that high-dose semaglutide (2.4 mg weekly) achieved NASH resolution without worsening of fibrosis in 59% of patients versus 17% with placebo

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