5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule that stops NNMT (Nicotinamide N-methyltransferase) from working
Vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and platelet-derived growth factor (PDGF), along with their receptors, are key proangiogenic factors
It is necessary for skin repair
The clinical implication is that intermittent pulsatile dosing, rather than multiple daily injections, is the strategy most consistent with preserving receptor sensitivity for either compound
But that delicate structure, so carefully preserved, is also incredibly vulnerable when its time to wake it up
Days 28-45: Gradual decline