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Prednisolone is a corticosteroid used to treat inflammatory and autoimmune conditions, whilst Wegovy (semaglutide 2.4 mg) is a GLP-1 receptor agonist licensed for chronic weight management in specific patient groups

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The redistribution happens even in women whose total weight stays stable, meaning the scale might not change while the composition of body fat shifts in dangerous directions

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Although our primary analyses focused on AOM tirzepatide and AOM semaglutide, we extracted dispense data for all GLP-1 RAs to examine overall treatment transitions and identify which therapies patients switched to

In this double-blind trial of 1,961 adults with a body mass index (BMI) of 30 or higher, adults on high dose 2.4 mg of weekly semaglutide (compared with the usual type 2 diabetes dose of 0.5mg or 1mg) lost an average 14.9% of baseline body weight after 68 weeks of treatment versus only 2.4% for a group on placebo and lifestyle intervention alone