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The local mechanisms of these effects are still under investigation, but GLP-1R co-expresses with proteins known to play an important role in appetite, such as prolactin-releasing peptide and tyrosine hydroxylase [42, 43]

Timing of administration can influence efficacy

Cell Metab 26: 753763.e7, 2017

The production of DAG is associated with the activation of protein kinase C (PKC), which is believed to regulate both lipolysis and other metabolic processes involved in lipid management