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CD4 + CD25 + FOXP3+) normally suppress autoreactive lymphocytes, but in HT, both their number and suppressive function are reduced, correlating with disease severity (Chen et al., 2023)

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Tuttle KR, Agarwal R, Alpers CE, Bakris GL, Brosius FC, Kolkhof P, Uribarri J

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It is found in many species including bacteria, yeast, mammals, and plants