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46 The mainstream view holds that the canonical GLP-1 receptor is not expressed in the human liver, and any hepatic effects are likely mediated through extrahepatic mechanisms rather than direct action

The drug half-life of approximately seven days means that it takes about five weeks to fully clear your system regardless of dosing frequency

Glossary CKD c hronic kidney disease CNS central nervous system CVD c ardiovascular disease FDA Food and Drug Administration GLP-1 glucagon-like peptide-1 GLP-1s glucagon-like peptide-1 receptor agonists HF Heart failure MASH metabolic dysfunction-associated steatohepatitis OA osteoarthritis OSA obstructive sleep apnea PAD peripheral arterial disease SC subcutaneous T2DM type 2 diabetes mellitus U.S

The enhanced GI effects may cause temporary water weight shifts, while the stronger appetite suppression can lead to reduced food intake that shows up as an artificially steep drop on the scale