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A P 2PN) (7.74.7)%, and 24 showed degeneration (23.33.8)%
By making small lifestyle changes and working closely with a healthcare team, you can manage these symptoms effectively
Last reviewed: May 24, 2026 Last updated: May 24, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Constipation affected 30.7% of those on CagriSema, compared with 11.6% on placebo, and vomiting affected 26.1% versus 4.1%
In the retatrutide Phase 2 trial (Jastreboff et al., NEJM 2023), many participants found that symptoms such as diarrhoea, nausea, and abdominal discomfort improved after the initial weeks at a given dose, consistent with experience seen with licensed GLP-1 receptor agonists
