Gastrointestinal discomfort may occur in some individuals
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Others may experience intermittent symptoms depending on meal size, composition, and individual sensitivity to delayed gastric emptying., Clinical note: In real-world clinical practice, acute episodes triggered by a specific meal often resolve within 24 hours as gastric emptying progresses
A patient on Wegovy 2.4 mg who starts tirzepatide at 10 mg rather than 2.5 mg would be introducing a novel molecule at a dose far higher than the tolerability data support for initiators [1][6]
The evolutionary origin of exendin genes ( exendin 14) has not been fully resolved but it seems likely that exendins evolved by duplication from a glucagon-like peptide gene precursor 14