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Biomarker Changes After Discontinuation: A Personalized Framework Biomarkers offer valuable context for understanding how quickly metabolism shifts after tirzepatide withdrawal

Top-line results from the SELECT trial were released last month showing that semaglutide 2.4 mg reduces the risk of major adverse cardiovascular events in adults with overweight or obesity

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Understanding where this field is heading helps contextualize the current choice between these two agents

However, because tesofensine has an extraordinarily long half-life (200+ hours), this initial peak is less clinically significant than the cumulative buildup that occurs over the first 1014 days of daily dosing once steady state is reached, plasma levels remain relatively constant throughout the 24-hour dosing interval

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