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( d-f ) Representative images of SemaTRAP (n = 3 mice) (left side) or VehTRAP (n = 2 mice) (right side) cells (magenta) and semaglutide induced Fos immunolabeled cells (green) in AP/NTS ( d ), PBN ( e ), and CeA ( f )

the dose was then increased to 5 mg for the remaining 8 weeks

They include: Nausea the most commonly reported symptom, typically peaking in the first one to two weeks after a dose change Diarrhoea and constipation both can occur, sometimes alternating Vomiting less common than nausea but reported by some patients at higher doses Abdominal discomfort or bloating Diet-related side effects occur when patients eat too little, too quickly, or consume high-fat meals

J Neurol 272 , 226 (2025)

Always follow the recommended amount and consult a healthcare professional if you have specific health concerns

These receptor agonists have been used successfully to treat type 2 diabetes mellitus (T2DM), which is a frequent co-morbidity of obesity