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[1] [8] Oral vs Injectable B12: Dosage Differences The route of B12 administration significantly affects the required dosage due to differences in bioavailability and absorption mechanisms

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Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]

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